中性球及其誘引激素在周圍神經瓦勒氏變性的角色
Date Issued
2003-10-31
Date
2003-10-31
Author(s)
簡雄飛
DOI
912314B002331
Abstract
MCP-1 is the major chemokine expressed
during Wallerian degeneration for attracting
monocytes. However, we observed similar
influx of macrophages within the
degenerating sciatic nerves of MCP-1
knocked out mice, with a delay of about 2-3d
in the extent of degeneration. Besides, there
is a small peak of CINC (The chemokine for
neutrophils) expression on 1 d post-axotomy.
We observed early influx of neutrophils at 1
to 3 d within the Wallerian degeneration
models. By double labeling with ED1 and
MCA967 (anti-neutrophil ab), we noted that
neutrophils come first and fast and are
replaced with macrophages later just as in
other inflammation processes. Thus we could
explain why macrophages still infiltrating
within the degenerating sciatic nerve of
MCP-1 KO mice. The upstream position of
the role that neutrophils play makes the
downstream MCP-1 knockout ineffective.
Besides, there is a redundancy of monocyte
chemokines.
Subjects
nerve degeneration
nerve
regeneration
regeneration
peripheral nerves
neutrophils
Publisher
臺北市：國立臺灣大學醫學院外科
Type
report
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