Possible Combined Effects of Plasma Folate Levels, Global DNA Methylation, and Blood Cadmium Concentrations on Renal Cell Carcinoma
Journal
Nutrients
Journal Volume
15
Journal Issue
4
Date Issued
2023
Author(s)
Chen, Wei-Jen
Lee, Hui-Ling
Lin, Ying-Chin
Huang, Ya-Li
Shiue, Horng-Sheng
Hsueh, Yu-Mei
Abstract
levels were associated with decreasing odds ratio (OR) of RCC. Although plasma folate levels were not directly associated with 5mdC (%), a combined effect was observed with the odds of low plasma folate levels and low 5mdC (%) were greater among RCC patients compared to controls (OR (95% confidence interval, CI) = 11.86 (5.27-26.65)). Additionally, we observed that the odds of low plasma folate and high blood cadmium levels were greater among RCC patients than in controls (OR (95% CI): 8.15 (1.39-7.13)). This study provides suggestive evidence that plasma folate levels may modify the associations between 5mdC (%) or blood cadmium concentrations and RCC.
SDGs
Type
journal article