Determination of 38 pharmaceuticals and personal care products in water by lyophilization combined with liquid chromatography-tandem mass spectrometry
Journal
Analytical Methods
Journal Volume
13
Journal Issue
3
Pages
299-310
Date Issued
2021
Author(s)
Abstract
A convenient, effective, and low-cost method was developed for the determination of 38 pharmaceuticals and personal care products (PPCPs), including 19 antibiotics in surface water samples by lyophilization combined with liquid chromatography-tandem quadrupole mass spectrometry (LC-MS/MS). The components of the extraction solvent, the volume of the water sample, and the volume of extraction solvent were successively optimized. The analytes in 80 mL water samples were concentrated by lyophilization, eluted effectively by the solvent of 2 mL acetonitrile, 2 mL acetone, and 2 mL ultrapure water. The method detection limits ranged from 0.02 ng L-1 (caffeine) to 0.17 μg L-1 (glibenclamide). The recoveries of 30 analytes ranged from 40.0% (sulfaguanidine) to 124.4% (flumequine). The relative standard deviations of all analytes were below 21% except ciprofloxacin (29%). The performance of the optimized method was comparable to the solid phase extraction and ultrasonic extraction method with much less consumption of labor, organic solvent, and consumables. The developed method was successfully applied to surface river water, reservoir water, and effluent of the wastewater treatment plant. This journal is © The Royal Society of Chemistry.
Subjects
Acetone; Antibiotics; Effluent treatment; Liquid chromatography; Mass spectrometry; Organic solvents; Phase separation; Reservoirs (water); Sewage treatment plants; Solvent extraction; Surface waters; Ultrasonic applications; Wastewater treatment; Extraction solvents; Liquid chromatography-tandem mass spectrometry; Method detection limits; Pharmaceuticals and personal care products; Relative standard deviations; Solid-phase extraction; Ultrasonic extraction; Wastewater treatment plants; Effluents; cosmetic; drug; water; freeze drying; liquid chromatography; tandem mass spectrometry; water pollutant; Chromatography, Liquid; Cosmetics; Freeze Drying; Pharmaceutical Preparations; Tandem Mass Spectrometry; Water; Water Pollutants, Chemical
Other Subjects
Acetone; Antibiotics; Effluent treatment; Liquid chromatography; Mass spectrometry; Organic solvents; Phase separation; Reservoirs (water); Sewage treatment plants; Solvent extraction; Surface waters; Ultrasonic applications; Wastewater treatment; Extraction solvents; Liquid chromatography-tandem mass spectrometry; Method detection limits; Pharmaceuticals and personal care products; Relative standard deviations; Solid-phase extraction; Ultrasonic extraction; Wastewater treatment plants; Effluents; cosmetic; drug; water; freeze drying; liquid chromatography; tandem mass spectrometry; water pollutant; Chromatography, Liquid; Cosmetics; Freeze Drying; Pharmaceutical Preparations; Tandem Mass Spectrometry; Water; Water Pollutants, Chemical
Type
journal article