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  3. National Taiwan University Hospital / 醫學院附設醫院 (臺大醫院)
  4. Association of epicardial adipose tissue with coronary atherosclerosis is region-specific and independent of conventional risk factors and intra-abdominal adiposity
 
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Association of epicardial adipose tissue with coronary atherosclerosis is region-specific and independent of conventional risk factors and intra-abdominal adiposity

Journal
Atherosclerosis
Journal Volume
213
Journal Issue
1
Pages
279-287
Date Issued
2010-11
Author(s)
TZUNG-DAU WANG  
WEN-JENG LEE  
FUH-YUAN SHIH  
CHIEN-HUA HUANG  
WEN-JONE CHEN  
Lee Y.-T.
TIFFANY TING-FANG SHIH  
MING-FONG CHEN  
DOI
10.1016/j.atherosclerosis.2010.07.055
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/466139
https://www.scopus.com/record/display.uri?eid=2-s2.0-77958487910&doi=10.1016%2fj.atherosclerosis.2010.07.055&origin=inward&txGid=8616534b5181e6d52bb418ce9ba4a794
Abstract
Objective: To elucidate which measurement of epicardial adipose tissue (EAT) best reflects its atherogenic risk, we examined the associations between different EAT measurements and various atherosclerotic parameters of the entire coronary tree and individual coronary arteries. Methods: This study included 224 consecutive patients underwent multidetector computed tomography before diagnostic coronary angiography. Regional thickness, cross-sectional areas, and total volume of EAT were measured. Four atherosclerotic parameters, including severity score, extent score, calcium volume score, and number of coronary arteries with ?50% luminal stenosis, of the entire coronary tree and individual coronary arteries were assessed. Results: Both total EAT volume and thickness of EAT in the left atrioventricular groove were unanimously associated with the presence of coronary atherosclerosis dichotomously defined by the 4 scoring systems. However, only EAT thickness in the left atrioventricular groove, but not total EAT volume, was significantly associated with all 4 parameters of coronary atherosclerosis in a dose-dependent manner, even after adjustments for conventional risk factors, body-mass index, waist circumference, C-reactive protein, and intra-abdominal visceral fat area. Using the receiver-operating-characteristic analysis, 12.2 mm was the optimal cutoff point for left atrioventricular groove thickness to predict the presence of significant coronary stenosis (?50% diameter stenosis). Among the three coronary arteries, left atrioventricular groove thickness was most strongly correlated with ?50% diameter stenosis in the embedded left circumflex artery by multivariate regression model. Conclusions: Thickness of EAT in the left atrioventricular groove provides a more accurate assessment of its atherogenic risk and is therefore a better coronary risk factor than total EAT volume. ? 2010 Elsevier Ireland Ltd.
Subjects
Atherosclerosis; Coronary disease; Fat; Risk factor; Tomography
SDGs

[SDGs]SDG3

Other Subjects
calcium; adipose tissue; adult; angiocardiography; article; computed tomography scanner; coronary artery atherosclerosis; coronary artery obstruction; epicardium; female; human; major clinical study; male; multidetector computed tomography; priority journal; quantitative analysis; risk factor; scoring system; Adipose Tissue; Adiposity; Aged; Angina Pectoris; Coronary Angiography; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Pericardium; Risk; Risk Factors; ROC Curve
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

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