Role of hepatitis B virus precore/core promoter mutations and serum viral load on noncirrhotic hepatocellular carcinoma: A case-control study
Journal
Journal of Infectious Diseases
Journal Volume
194
Journal Issue
5
Pages
594-599
Date Issued
2006
Author(s)
Abstract
Background. Apart from the presence of liver cirrhosis, hepatitis B virus (HBV) factors have also been shown to play a role in the development of hepatocellular carcinoma (HCC). Studying HBV-related noncirrhotic HCC may help clarify the effect of viral factors. Methods. In a hospital-based, age- and genotype-matched study, we aimed to determine the role played by basal core promoter (BCP) T1762/A1764 mutation, precore A1896 mutation, and serum viral load in noncirrhotic hepatocarcinogenesis by comparing 44 patients with HBV-related noncirrhotic HCC, 45 patients with chronic hepatitis B, and 42 patients with HBV-related cirrhotic HCC. HBV genotype, precore and BCP mutations, and viral load were determined by molecular assays. Results. In univariate analysis, statistically significant odds ratios were obtained for male sex (P = .005) and BCP T1762/A1764 mutation (P = .0003) in patients with noncirrhotic HCC, compared with patients with chronic hepatitis B. By multiple logistic regression analysis, male sex, BCP T1762/A1764 mutation, and viral load ?=105 copies/mL were independently associated with the risk of noncirrhotic HCC. The virologic characteristics were similar between patients with cirrhotic HCC and those with noncirrhotic HCC. Conclusions. Our results suggest that BCP T1762/A1764 mutation and higher viral load may be involved in the carcinogenesis of cirrhotic and noncirrhotic HCC. ? 2006 by the Infectious Diseases Society of America. All rights reserved.
SDGs
Other Subjects
adenine; core protein; precore protein; thymine; unclassified drug; adult; article; basal core promoter; case control study; chronic hepatitis; clinical article; controlled study; female; gender; gene mutation; genotype; hepatitis B; Hepatitis B virus; human; infection risk; liver carcinogenesis; liver cell carcinoma; liver cirrhosis; male; multivariate logistic regression analysis; nonhuman; priority journal; promoter region; risk factor; univariate analysis; virus load; virus mutation
Publisher
University of Chicago Press
Type
journal article