Evaluation of low-dosage environmental mutagens with a long- term,cultured epithelial cell line
Resource
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY v.56 pp.919-25
Journal
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
Journal Volume
v.56
Pages
919-25
Date Issued
1996
Date
1996
Author(s)
LI, CHIH-SHAN
LIN, RONG-HWA
Abstract
A long-term cultured epithelial cell assay system developed from this investigation is very sensitive to very low concentrations of BaP and BaA. Although, the biological functions of Hela cells might not be the same as those of normal cells, Hela cells are still a promising cell line for evaluation. In addition, Hela cells are a cloned cell line and can easily grow in large quantities. Thisepithelial cell assay system may be a very useful tool for evaluating more environmental chemicals for their mutagenic effects on the respiratory tract. Furthermore, there is a need for further studies of this technique to examine the questions of how good a predictor of carcinogenicity it is.
Subjects
MUTAGEN
HELA CELL
ENVIRONMENT
Type
journal article