Synthesis of Anti-Microtubule N-(2-Arylindol-7-yl)-benzenesulfonamide Derivatives and Their Antitumor Mechanisms
Resource
CHEMMEDCHEM, 5(9), 1489-1497
Journal
ChemMedChem
Pages
1489-1497
Date Issued
2010
Date
2010
Author(s)
Chiou, Chun-Tang
Chen, Grace Shiahuy
Chen, Meng-Ling
Li, Huoming
Shi, Lei
Huang, Xiang-Hong
Dai, Wei-Ming
Abstract
Breaking the cycle: A series of N-(2-arylindol-7-yl)benzenesulfonamide derivatives were prepared. Among them, compound 2 showed promising antiproliferative activity against hormone-resistant prostate cancer PC-3 cells, induced G2/M-phase arrest, and induced apoptosis through a caspase-dependent pathway. (Chemical Equation Presented). ? 2010 wiley-vch verlag gmbh & co. KGaA.
Subjects
Antimitotic agents; Apoptosis; Benzenesulfonamides; Cytotoxicity; Microtubules
SDGs
Other Subjects
(2 phenylindol 7 yl) 4 toluenesulfonamide; antineoplastic agent; benzenesulfonamide derivative; n (2 phenylindol 7 yl) 4 methoxybenzenesulfonamide; n (3 chloro 2 phenylindol 7 yl) 4 methoxybenzenesulfonamide; n (3 formyl 2 phenylindol 7 yl) 4 methoxybenzenesulfonamide; n (3 hydroxymethyl 2 phenylindol 7 yl) 4 methoxybenzenesulfonamide; n (3 piperidinomethyl 2 phenylindol 7 yl) 4 methoxybenzenesulfonamide; n [2 (4' biphenyl)indol 7 yl] 4 methoxybenzenesulfonamide; n [2 (4' methoxyphenyl)indol 7 yl] 4 methoxybenzenesulfonamide; n [2 (4' tolyl)indol 7 yl] 4 methoxybenzenesulfonamide; n [2 [4' (4'' methoxybenzenesulfonamido)phenyl]indol 7 yl] 4 methoxybenzenesulfonamide; n [3 (4 morpholino)methyl 2 phenylindol 7 yl] 4 methoxybenzenesulfonamide; unclassified drug; antineoplastic activity; article; cancer cell culture; cell cycle arrest; cell cycle G2 phase; cell cycle M phase; controlled study; drug mechanism; drug potency; drug synthesis; human; human cell; IC 50; microtubule assembly; mitosis; priority journal; structure activity relation; Antineoplastic Agents; Cell Division; Cell Line, Tumor; Drug Screening Assays, Antitumor; G2 Phase; Humans; Indoles; Male; Microtubules; Prostatic Neoplasms; Structure-Activity Relationship; Sulfonamides; Tubulin Modulators
Type
journal article
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