Celecoxib enhances radiosensitivity in medulloblastoma-derived CD133-positive cells
Journal
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
Journal Volume
26
Journal Issue
11
Date Issued
2010-11
Author(s)
Chen, Kuan-Hsuan
Hsu, Chuan-Chih
Song, Wen-Shin
Huang, Chi-Shuan
Tsai, Chia-Chen
Kuo, Cheng-Deng
Hsu, Han-Shui
Tsai, Tung-Hu
Tsai, Ching-Yao
Chiou, Shih-Hwa
Lu, Kai-Hsi
Chen, Yi-Wei
Abstract
Cyclooxygenase-2 (COX-2), the enzyme that converts arachidonic acid to prostaglandins, is overexpressed in a variety of tumors, including medulloblastoma (MB). CD133, a transmembrane glycoprotein, has been suggested as a marker for cancer stem cells in brain tumors. The aim of the present study was to investigate the role of celecoxib, a selective COX-2 inhibitor, in enhancing the effects of ionizing radiotherapy (IR) on medulloblastoma-derived CD133-positive cells (MB-CD133(+)).
Subjects
CD133 | Celecoxib | Daoy | Medulloblastoma | Radiosensitivity
Type
journal article