C. elegans as a genetic model to identify novel cellular and molecular mechanisms underlying nervous system regeneration
Resource
CELL ADHESION & MIGRATION, 5(5), 387-394
Journal
Cell Adhesion & Migration
Pages
387-394
Date Issued
2011
Date
2011
Author(s)
Chiu, Hui
Alqadah, Amel
Chuang, Chiou-Fen
Chang, Chieh
Abstract
Research into conditions that improve axon regeneration has the potential to open a new door for treatment of brain injury caused by stroke and neurodegenerative diseases of aging, such as Alzheimer, by harnessing intrinsic neuronal ability to reorganize itself. Elucidating the molecular mechanisms of axon regeneration should shed light on how this process becomes restricted in the postnatal stage and in CNS and therefore could provide therapeutic targets for developing strategy to improve axon regeneration in adult CNS. In this review, we first discuss the general view about nerve regeneration and the advantages of using C. elegans as a model system to study axon regeneration. We then compare the conserved regeneration patterns and molecular mechanisms between C. elegans and vertebrates. Lastly, we discuss the power of femtosecond laser technology and its application in axon regeneration research.
Type
journal article
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