巨噬細胞與白色念珠菌交互作用中分泌性aspartyl proteinases所扮演的角色(2/2)
Other Title
The Role of Secreted Aspartyl Proteinases In the Macrophage - Candida
albicans Interaction (2/2)
albicans Interaction (2/2)
Date Issued
2003
Date
2003
Author(s)
陳宜君
DOI
912314B002130
Abstract
Growing evidences suggest that Candida
albicans secreted aspartyl proteinase 4,5,6
genes (SAP4-6) contribute to the
development of disseminated infections. Our
previous study demonstrated that Sap4-6
proteins are secreted during hyphae formation. In this study, the inhibitory effect of anti-Sap4-
6 antibodies in the multiplication of C. albicans
and the interaction with fluconazole were
studies. This study demonstrated that anti-Sap4-
6 antibodies exists in serum collected
from patients recovered from disseminated
candidiasis, but not from patients with C.
glabrata fungemia, or other critically ill
patients. Anti-Sap5 antiserum provided
stronger inhibitory effect on multiplication of C.
albicans wild type strain than pre-immune
control serum. This protective effect was not
significant for C. albicans wild type strain in
the presence of aspartic proteinase, pepstatin
A, for a ∆sap4-6 triple mutant, or for non-albicans
Candida species. Thus, this inhibitory
effect was at least in part through modulation
of the function of Sap4-6 proteins. Besides,
anti-Sap5 antibodies enhanced fluconazole
activity, a fungistatic agent. Our data provided
a rationale in development of vaccination to
immunocompromised patients with high risk of
disseminated candidiasis or passive
immunization for treatment in combination
with antifungal agent.
Subjects
Candida albicans
inhibitory
activity
activity
anti-Sap5 antiserum
SDGs
Publisher
臺北市：國立臺灣大學醫學院內科
Type
report
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