Sitagliptin use and thyroid cancer risk in patients with type 2 diabetes
Journal
Oncotarget
Journal Volume
7
Journal Issue
17
Pages
24871-24879
Date Issued
2016
Author(s)
Abstract
Whether sitagliptin may increase thyroid cancer risk has not been investigated in the Asian populations. This study evaluated the association in Taiwanese patients with newly diagnosed type 2 diabetes from 1999 to 2008 by using the reimbursement database of the National Health Insurance. They should have been followed for at least 6 months after March 1, 2009, the date when sitagliptin was approved for reimbursement. Patients newly treated with sitagliptin (n=58238, "ever users of sitagliptin") or other antidiabetic drugs (n =312853, "never users of sitagliptin") were followed until December 31, 2011. The treatment effect (for ever versus never users, and for tertiles of cumulative duration of therapy) was estimated by Cox regression incorporated with the inverse probability of treatment weighting using propensity score. Results showed that the respective number of incident thyroid cancer in ever users and never users was 28 and 172, with respective incidence of 29.34 and 22.13 per 100,000 person-years. The overall hazard ratio (95% confidence interval) of 1.516 (1.011-2.271) suggested a significantly higher risk associated with sitagliptin use. In tertile analyses, the hazard ratio for the first ( < 6.53 months), second (6.53-14.00 months) and third ( > 14 months) tertile of cumulative duration was 1.995 (1.015-3.919), 2.516 (1.451-4.364) and 0.595 (0.244-1.449), respectively. Analyses after excluding patients with benign thyroid disease and in a subsample matched on baseline characteristics supported the findings in the original sample. In conclusion, sitagliptin use is associated with an increased risk of thyroid cancer, especially during the first year of its treatment.
Subjects
Diabetes mellitus; Sitagliptin; Taiwan; Thyroid cancer
SDGs
Other Subjects
metformin; sitagliptin; sulfonylurea derivative; antidiabetic agent; sitagliptin; adult; Article; cancer risk; comorbidity; comparative study; controlled study; diabetic patient; disease association; disease duration; drug use; factual database; female; high risk population; human; major clinical study; male; medical record review; middle aged; non insulin dependent diabetes mellitus; patient monitoring; Taiwanese; thyroid cancer; treatment duration; chemically induced; non insulin dependent diabetes mellitus; pathology; thyroid tumor; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; Sitagliptin Phosphate; Thyroid Neoplasms
Publisher
Impact Journals LLC
Type
journal article