Phase I Dose-Escalation Study of Tirapazamine Chemoembolization for Unresectable Early- and Intermediate-Stage Hepatocellular Carcinoma
Journal
Journal of vascular and interventional radiology : JVIR
Journal Volume
33
Journal Issue
8
Pages
926
Date Issued
2022
Author(s)
Liu, Chang-Hsien
Peng, Cheng-Ming
Hwang, Jen-I
Abi-Jaoudeh, Nadine
Giiang, Lung-Hui
Tyan, Yu-Shen
Abstract
To investigate the safety of replacing doxorubicin with tirapazamine in conventional transarterial chemoembolization (TACE) in an Asian population with hepatocellular carcinoma (HCC), and to determine the optimal tirapazamine dose for phase II studies.
Subjects
TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION; DRUG-ELUTING BEADS; CANCER STEM-CELLS; TRANSARTERIAL CHEMOEMBOLIZATION; RANDOMIZED-TRIAL; LIVER-TUMORS; III TRIAL; EMBOLIZATION; HYPOXIA; CISPLATIN
SDGs
Publisher
ELSEVIER SCIENCE INC
Type
journal article