Electrochemical imaging of cells and tissues
Journal
Chemical Science
Journal Volume
9
Journal Issue
20
Start Page
4546
End Page
4554
ISSN
20416520
Date Issued
2018
Author(s)
Abstract
The technological and experimental progress in electrochemical imaging of biological specimens is discussed with a view on potential applications for skin cancer diagnostics, reproductive medicine and microbial testing. The electrochemical analysis of single cell activity inside cell cultures, 3D cellular aggregates and microtissues is based on the selective detection of electroactive species involved in biological functions. Electrochemical imaging strategies, based on nano/micrometric probes scanning over the sample and sensor array chips, respectively, can be made sensitive and selective without being affected by optical interference as many other microscopy techniques. The recent developments in microfabrication, electronics and cell culturing/tissue engineering have evolved in affordable and fast-sampling electrochemical imaging platforms. We believe that the topics discussed herein demonstrate the applicability of electrochemical imaging devices in many areas related to cellular functions. © 2018 The Royal Society of Chemistry.
Publisher
Royal Society of Chemistry
Type
review article