Combination of Photothermal and Photodynamic Inactivation of Cancer Cell through Surface Plasmon Resonance of Gold Nanoring
Date Issued
2015
Date
2015
Author(s)
Chu, Chih-Ken
Abstract
The more effective inactivation of oral cancer cell SAS through the combination the photothermal therapy (PTT) and photodynamic therapy (PDT) effects based on the localized surface plasmon resonance (LSPR) around 1064 nm in wavelength of Au nanoring (NRI) under femtosecond (fs) laser illumination is demonstrated. The PTT effect is caused by the LSPR-enhanced absorption of Au NRI. The PDT effect is generated by linking Au NRI with the photosensitizer of AlPcS for producing singlet oxygen through the LSPR-enhanced two-photon absorption (TPA) excitation of AlPcS. The laser threshold intensity for cancer cell inactivation with the applied Au NRI linked with AlPcS is significantly lower, when compared to that with the Au NRI not linked with AlPcS. The comparison of inactivation threshold intensity between the cases of fs and continuous laser illuminations at the same wavelength and with the same average power confirms the crucial factor of TPA under fs laser illumination for producing the PDT effect.
Subjects
Photosensitizer
Gold nanorings
Photodynamic therapy
Photothermal therapy
Sulfonated Aluminum Phthalocyanines
SDGs
Type
thesis
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