Adult methicillin-resistant Staphylococcus aureus bacteremia in Taiwan: clinical significance of non-multi-resistant antibiogram and Panton-Valentine leukocidin gene
Journal
Diagnostic Microbiology and Infectious Disease
Journal Volume
59
Journal Issue
4
Pages
365-371
Date Issued
2007
Author(s)
Abstract
It is poorly defined whether or not adult patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia with a non-multi-resistant antibiogram phenotype and Panton-Valentine leukocidin (PVL) gene carriage have different clinical syndromes. Clinical characteristics of 95 adult patients of MRSA bacteremia, with isolates that were non-multi-resistant to non-beta-lactam, were compared with a contemporaneous multiresistant group. Independent risk factors other than community-associated MRSA bacteremia patients associated with recovery of non-multi-resistant MRSA isolates by multivariate analysis included deep-seated infection and catheter insertion site infection. Older age, intensive care unit-onset bacteremia, and postoperative infection were negative independent risk factors associated with non-multi-resistant MRSA isolates. Most of the 60 recoverable non-multi-resistant MRSA isolates belonged to multilocus sequence type 59, and all isolates belonged to staphylococcal chromosomal cassette mec (SCCmec) element type IV or type V. Most PVL-positive MRSA isolates belonged to SCCmec V. PVL-positive CA-MRSA isolates could cause more deep-seated infections in patients presented with non-multi-resistant MRSA bacteremia.
SDGs
Type
journal article