Development of Implantable Enzyme Biosensors by Using Biomedical Polymer Protective Membrane
Date Issued
2008
Date
2008
Author(s)
Liu, Pei-Chun
Abstract
In our study, preparation of the three-electrode biosensors used the MEMS technology. The three-electrode biosensors measured glucose and lactate using glucose oxidase (GOD) and lactate dehydrogenase (LDH). Biomedical and implantable sensor applications require stable, reproducible, reversible, and reliable miniaturized reference electrode , made of biocompatible materials. So the present study reports the application of protective membrane on the device, which exists both biocompatibility and permselectivity, and acts as a surface coating material for the outer layer of the Bio-sensor. For miniaturization of sensing system, we design a single-supply circuit. Thus, our study used difference protective membrane to assure the long-term stability of the Ag/AgCl reference electrode. From those results, we can know that reference electrode with polyurethane protective membrane is more stable than the one without protective membrane. In vivo performance, the sensor with polyurethane protective membrane can also work when implanted subcutaneously in a rat.
Subjects
Micro-Electro-Mechanical System
Implant
Enzyme biosensor
Lactate dehydrogenase
Glucose Oxidase
Polyurethane membrane
Type
thesis
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