Pyridoxal Phosphate-Responsive Epilepsy with Resistance to Pyridoxine
Resource
PEDIATRIC NEUROLOGY v.26 n.2 pp.146-147
Journal
PEDIATRIC NEUROLOGY
Journal Volume
v.26
Journal Issue
n.2
Pages
146-147
Date Issued
2002
Date
2002
Author(s)
KUO, MENG-FAI
Abstract
We present a female infant with seizures responsive to pyridoxal phosphate but that are resistant to pyridoxine. The mechanism by which pyridoxal phosphate controls seizures in this patient is unknown. Her seizures are perhaps not solely caused by pyridoxal phosphate deficiency. It is suggested that in addition to glutamic acid decarboxylase abnormality, the path from the absorption, transportation, phosphorylation , and oxidation of pyridoxine to pyridoxal phosphate in this patient might be defective. It should be considered whether pyridoxal phosphate can be the drug of choice instead of pyridoxine in treating patients suspected of pyridoxine-dependent epilepsy to reduce failure rate and further delay in seizure control. (C) 2002 by Elsevier Science Inc. All rights reserved.
Subjects
LOW-DOSE CORTICOTROPIN
DEPENDENT SEIZURES
INFANTILE SPASMS
Type
journal article