S-Linked sialyloligosaccharides bearing liposomes and micelles as influenza virus inhibitors
Journal
Organic and Biomolecular Chemistry
Journal Volume
13
Journal Issue
47
Pages
11518
Date Issued
2015
Author(s)
Abstract
An efficient, homogeneous synthesis of phospholipid conjugation of S-Neu5Acα2-6Galβ1-4GluNAcβ1-3 (3) and its 6-sulphate analogue 4 has been developed. The self-assembled micelles and liposomes of these trisaccharides formed in solution were found to be inhibitors interfering with the entry of the H1N1 influenza virus into MDCK cells. Compound 3 bearing a liposome and a micelle displayed superior inhibitory activity than its 6-sulfate congener 4 in both the virus neutralization assay and the hemagglutination inhibition assay.
SDGs
Type
journal article