Association between dyslipidemia and residual renal function in patients on chronic peritoneal dialysis
Journal
Clinical Nephrology
Journal Volume
70
Journal Issue
3
Pages
233-239
Date Issued
2008
Author(s)
Abstract
Background: Dyslipidemia and residual renal function (RRF) have a significant impact on the cardiovascular mortality in dialysis patients, but their association in patients on chronic peritoneal dialysis (PD) has not been completely studied. Methods: 170 PD patients were divided into 2 groups based on the RRF (Group I had no RRF and Group II had RRF > 0 ml/min/1.73 m2 BSA). An observational, longitudinal study was performed to elucidate the dyslipidemic state in PD patients with different levels of RRF and the associafion of dyslipidemia and deterioration of RRF during 3 years. Results: Patients' basic characteristics and lipid profiles at the initiation of study were similar between the groups. At the end of study, Group I patients had a lower T-CHO (p = 0.001), LDL-C (p = 0.018), HDL-C (p = 0.05) and non-HDL-C (p = 0.003) than Group II. There was a significant correlation between a change in HDL-C and the decline of RRF (r = 0.177, p = 0.048) and it was independent of PD duration and levels of highly sensitive C-reactive protein (r = 0.233, p = 0.04). Conclusion: Our results clearly demonstrate the different longitudinal changes of lipid profiles in PD patients with different RRF and an association between decline of HDL-C and deterioration of RRF. ?2008 Dustri-Verlag Dr. K. Feistle.
SDGs
Other Subjects
albumin; angiotensin receptor antagonist; antihypertensive agent; C reactive protein; calcium; cholesterol; creatinine; dialysis fluid; dipeptidyl carboxypeptidase inhibitor; erythropoietin; hemoglobin; high density lipoprotein cholesterol; hydroxymethylglutaryl coenzyme A reductase inhibitor; lipid; low density lipoprotein cholesterol; parathyroid hormone; phosphorus; potassium; uric acid; adult; aged; anemia; article; body mass; chronic glomerulonephritis; chronic kidney failure; continuous ambulatory peritoneal dialysis; controlled study; correlation analysis; creatinine clearance; deterioration; diabetes mellitus; diabetic nephropathy; diastolic blood pressure; disease association; dyslipidemia; female; human; hypertension; kidney function; longitudinal study; major clinical study; male; observational study; peritoneal dialysis; systolic blood pressure; Taiwan; treatment duration; university hospital
Publisher
Dustri-Verlag Dr. Karl Feistle
Type
journal article