A Family-based Association Study of Histamine N-methyltransferase Gene and Schizophrenia with Early Onset and Sustained Attention Deficits
Date Issued
2009
Date
2009
Author(s)
Wu, Yun-Hsuan
Abstract
Objective. To examine the association between histamine N-methyltransferase (HNMT) gene and schizophrenia with early onset and sustained attention deficit using family-based association.ethods. The families in this study were part of the sample from the Taiwan Schizophrenia Linkage Study (TSLS) on the basis of a previous ordered subset analysis (OSA): 206 families of patients with early onset and sustained attention deficits. All participants were interviewed by trained research assistants who used the Diagnostic Interview for Genetic Studies (DIGS), and drawn for peripheral blood. Six SNPs of the HNMT gene were genotyped and FBAT program was used to perform single-locus and haplotype association analyses. Multiple testing was adjusted by means of effective marker number estimated using SNPSpD program.esults. There was no association between individual SNPs of HNMT and schizophrenia in this subset of families. When employing two-, three-, four-, five-, and six-marker sliding window analysis for haplotype association in these families, the result for the four-marker haplotype of rs3100701-rs3791244-rs3791242-rs11558538 haplotype A-G-T-G with schizophrenia had a p-value of 0.012, which was smaller than the threshold for significance (0.013) when adjusted for the effective marker number of four in this study.onclusions. There was a significant association between HNMT gene and schizophrenia with early onset and sustained attention deficits, and future replication in independent samples is warranted
Subjects
family-based association
histamine N-methyltransferase
schizophrenia
Type
thesis
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