Design of a Compact Disk (CD) Microfluidic Platform for Generation of Specific Solution Concentrations
Date Issued
2006
Date
2006
Author(s)
Chang, Yi-Fang
DOI
en-US
Abstract
The goal of this thesis is to design a microfluidic platform on a compact disk (CD) that performs generation of concentration. Design concept consists of two supply reservoirs, two receiving reservoirs, and four main channels. The microchannel geometries are varied in order to attain a particular concentration. The CD microfluidic platform was fabricated using CO2 laser engraver on the material poly(methylmethacrylate) (PMMA). PMMA was chosen due to that it is inexpensive, transparent, and ease of fabrication without a cleanroom. Channel encapsulation was performed using gloss cold lamination film, with the material polyvinyl chloride (PVC). Fluid samples used were red food dye and clear water. The spin protocol was just one step with rotational speed at 5,000 RPM, under negligible acceleration.
Results show distinct concentration between 0% to 100% was obtained. Concentrations of 30.6%, 40.6%, 50.7%, 60.5% are obtained due to changes in channel width and length as designed. Analysis by gray level from 0% to 100% proves that it is a simple and accurate way to measure concentration gradient. The proposed design using centrifugal-based platform can provide convenient and speedy way for generation of concentration. However, accuracy is not as good as expectation; the difference between analysis and experimental concentration was within 10%. Roughness, bubble formation and Coriolis force in the structure are believed to be the key problems that need to be improved. This CD microfluidic platform might be useful to rapidly attain the desired concentration for chemical and/or biology applications.
Subjects
光碟片(CD)
離心力
濃度
微流
compact disk
centrifugal force
concentration
microfluidics
Type
thesis
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