Association of circulating matrix metalloproteinase-1, but not adiponectin, with advanced coronary artery disease
Journal
Atherosclerosis
Journal Volume
204
Journal Issue
1
Pages
293-297
Date Issued
2009
Author(s)
Huang P.-J.
Lai S.-K.
Abstract
Objective: Recent evidence suggests that high tissue matrix metalloproteinase-1 (MMP-1) and low adiponectin may serve as biomarkers of atherosclerosis. Results on the associations of circulating MMP-1 and adiponectin concentrations are scarce. We hypothesized that patients with multivessel coronary artery disease (CAD) have elevated high-sensitivity C-reactive protein (hs-CRP), MMP-1 but low adiponectin levels, and concomitant measurements of these biomarkers could improve predictive strength for advanced CAD. Research design and methods: We analyzed concentrations of MMP-1, hs-CRP and adiponectin in 217 subjects with angiographically documented multivessel CAD (two-, or three-vessel disease by luminal stenosis ?50%) and 81 controls. MMP-1 and hs-CRP were notably higher in patients with CAD; while adiponectin was not significantly different between two groups. Levels of hs-CRP positively correlated with body mass index and left ventricular dysfunction (R2 = 0.16, P < 0.0001); while adiponectin was significantly associated with age, gender, and levels of cholesterol and triglyceride (R2 = 0.09, P < 0.0001). On the contrary, MMP-1 was not associated with any clinical cardiovascular risk factors, and still an independent predictor (OR = 1.49, P < 0.0001) of multivessel CAD after the adjustment of clinical risk factors and hs-CRP. Conclusion: Elevated MMP-1 and hs-CRP, but not low adiponectin concentrations, could predict the presence of advanced coronary atherosclerosis. In addition, MMP-1 may serve as a more specific marker for significant CAD independent of hs-CRP. ? 2008 Elsevier Ireland Ltd. All rights reserved.
SDGs
Other Subjects
adiponectin; angiotensin 2 receptor antagonist; antilipemic agent; biological marker; C reactive protein; cholesterol; dipeptidyl carboxypeptidase inhibitor; hydroxymethylglutaryl coenzyme A reductase inhibitor; interstitial collagenase; triacylglycerol; adult; age determination; aged; arterial circulation; article; body mass; cardiovascular risk; cholesterol blood level; control group; controlled study; coronary artery atherosclerosis; coronary artery disease; coronary artery obstruction; diabetes mellitus; echocardiography; female; heart left ventricle failure; human; hyperlipidemia; hypertension; major clinical study; male; obesity; priority journal; protein blood level; risk factor; sensitivity analysis; sex determination; triacylglycerol blood level; Adiponectin; Aged; Biological Markers; C-Reactive Protein; Case-Control Studies; Coronary Angiography; Coronary Artery Disease; Disease Progression; Female; Humans; Linear Models; Logistic Models; Male; Matrix Metalloproteinase 1; Middle Aged; Predictive Value of Tests
Type
journal article