Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Medicine / 醫學院
  3. School of Medicine / 醫學系
  4. Kidney volume and plasma hepatocyte growth factor-transforming growth factor β1 ratio among children with biliary atresia before and after liver transplantation: The reversibility of nephromegaly
 
  • Details

Kidney volume and plasma hepatocyte growth factor-transforming growth factor β1 ratio among children with biliary atresia before and after liver transplantation: The reversibility of nephromegaly

Journal
American Journal of Kidney Diseases
Journal Volume
46
Journal Issue
5
Pages
830-836
Date Issued
2005
Author(s)
Cheng C.-H.
Tsau Y.-K.
I-JUNG TSAI  
DOI
10.1053/j.ajkd.2005.07.033
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-27144438537&doi=10.1053%2fj.ajkd.2005.07.033&partnerID=40&md5=0fedf24b08897d005d6e9df216f7a829
https://scholars.lib.ntu.edu.tw/handle/123456789/530119
Abstract
Background: We previously showed a positive correlation between nephromegaly and plasma hepatocyte growth factor (HGF)/transforming growth factor β1 (TGF-β1) ratio in children with biliary atresia. The purpose of this study is to examine the possible reversibility of nephromegaly in patients with biliary atresia. Methods: We evaluated kidney volume in 13 patients with biliary atresia before and after liver transplantation, 6 patients with hepatoblastoma, and 26 healthy children. Plasma HGF and TGF-β1 levels were determined for all children. Results: We noted significant nephromegaly in children with biliary atresia before liver transplantation compared with healthy children and children after liver transplantation (P < 0.001 and P = 0.006 for intercepts, P = 0.064 and P = 0.753 for slopes by analysis of covariance, respectively). The highest plasma HGF levels and HGF/TGF-β1 ratios and the lowest TGF-β1 concentrations were found in children with biliary atresia before liver transplantation (P < 0.001). No statistically significant nephromegaly was observed in children with biliary atresia after liver transplantation or those with hepatoblastoma despite the presence of a mildly increased plasma HGF level and HGF/TGF-β1 ratio. Plasma HGF/TGF-β1 ratio correlated positively with degree of nephromegaly in all patients (r = 0.717; P < 0.001). Conclusion: Our data suggest that liver transplantation reverses the nephromegaly present in children with biliary atresia and that plasma HGF/TGF-β1 ratio may be associated with the development of nephromegaly in patients with biliary atresia. ? 2005 by the National Kidney Foundation, Inc.
Subjects
Biliary atresia; Hepatoblastoma; Hepatocyte growth factor; Liver transplantation; Nephromegaly; Transforming growth factor β1
SDGs

[SDGs]SDG3

Other Subjects
scatter factor; transforming growth factor beta1; article; bile duct atresia; child; clinical article; controlled study; correlation analysis; disease association; hepatoblastoma; human; infant; kidney hypertrophy; liver transplantation; statistical analysis; statistical significance; Biliary Atresia; Biological Markers; Child; Child, Preschool; Female; Hepatoblastoma; Hepatocyte Growth Factor; Humans; Infant; Kidney; Liver Neoplasms; Liver Transplantation; Male; Organ Size; Postoperative Period; Transforming Growth Factor beta; Transforming Growth Factor beta1
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science