Colon Perforation as Initial Manifestation of Post-transplant Lymphoproliferative Disorder Following Kidney Transplant: Report of a Case
腎移植後淋巴增生疾病造成結腸穿孔：病例報告
Journal
Formosan Journal of Surgery
Journal Volume
41
Journal Issue
4
Pages
158 - 162
Date Issued
2008
Author(s)
Abstract
A 39 year-old female suffered 2 days of abdominal pain approximately 11 months after cadaveric kidney transplantation. Emergent laparotomy revealed transverse colon ulceration with perforation and left ovarian tumor. Ulceration debridment, loop colostomy of the transverse colon, and left oophorectomy were carried out. Her post-operative course was uncomplicated. The pathological examination revealed polymorphic post-transplant lymphoproliferative disorder. Consequently immunosuppressants were reduced to half of the original dose and anti CD-20 antibody was given to this patient. Complete remission was noted after 4 doses of anti-CD-20 antibody. Colon perforation as the initial presentation of post-transplant lymphoproliferative disorder (PTLD) is unusual. However, early detection is necessary and aggressive investigation should be considered in suspicious cases with a high-risk of PTLD.
SDGs
Type
journal article