A Concise Route to Keto-Bridged Polyphenols by Photo-Fries Rearrangement in Flow
Journal
Chemistry-An Asian Journal
Journal Volume
19
Journal Issue
13
ISSN
1861-4728
1861-471X
1861-4728
Date Issued
2024-05-28
Author(s)
Abstract
Described is a new synthetic route to bis(2-hydroxy-3,5-di-t-butylphenyl)methanone and its derivatives. The combined esterification/photo-Fries rearrangement approach enables a modular preparation of keto-bridged polyphenols. This protecting group-free process is highly atom- and step-economic, and a scalable production was easily achieved in the continuous-flow mode.
Subjects
hydroxybenzophenone
oxygen donor ligand
phenol
photo-Fries rearrangement
photoflow synthesis
Publisher
Wiley
Type
journal article