Noninvasive assessment of liver function reserve with fluorescent dosimetry of indocyanine green
Journal
Biomedical Optics Express
Journal Volume
13
Journal Issue
4
Date Issued
2022-04-01
Author(s)
Wu, Pei Chun
Guo, Lun Zhang
Yu, Shan
Zeng, Ning
Liu, Yu Cheng
Yu, Jia
Zhang, Zhiming
Lu, Ke
Sun, Liangyu
Wang, Chunfei
Chang, Yu Han
Lu, Yin Lin
Shen, Yu Fang
Tai, Sheng
Annie Ho, Ja An
Liu, Tzu Ming
Abstract
Using in vivo multiphoton fluorescent dosimetry, we demonstrate that the clearance dynamics of Indocyanine Green (ICG) in the blood can quickly reveal liver function reserve. In normal rats, the ICG retention rate was below 10% at the 15-minute post-administration; While in the rat with severe hepatocellular carcinoma (HCC), the 15-minute retention rate is over 40% due to poor liver metabolism. With a 785 nm CW laser, the fluorescence dosimeter can evaluate the liver function reserve at a 1/10 clinical dosage of ICG without any blood sampling. In the future, this low-dosage ICG 15-minute retention dosimetry can be applied for the preoperative assessment of hepatectomy or timely perioperative examination.
Type
journal article