Development of carbohydrate-based anti-breast cancer vaccines
Date Issued
2009
Date
2009
Author(s)
Lin, Yu-Chen
Abstract
Abstractlobo H was first isolated and identified by the monoclonal antibody, MBr1 in 1984 by Hakomori et al. It was found minor expressed in normal human mammary gland epithelia but over-expressed on breast cancer, lung cancer, prostate cancer, pancreas cancer, stomach cancer, and ovary cancer and just minor expressed in normal human mammary gland epithelia. Based on the significant difference between normal cells and cancer cells, Globo H was considered to be a good candidate for carbohydrate-based anti-cancer vaccine. Recently, Globo H, SSEA-3, and SSEA-4, especially the later two, were found largely on cancer stem cells. They are also belong to globo-series. These two antigens have provided a new direction for cancer stem cell targeting vaccine design.n this study, these three antigens were combined with DT-CRM197 and adjuvant, respectively. Globo H-DT induced large amount of antibodies not only anti-Globo H but also anti-SSEA-3 and anti-SSEA-4 antibodies. SSEA-4-DT induced antibodies with high spcificity. On the other hand, SSEA-3-DT which lack of fucose or sialic acid showed low specificity. More interestingly, all these three vaccines can induce much higher IgG titer than IgM., these vaccine with long-term protective efficiency is worth waiting for. .hese results are very exciting, and synthesize of different glycodendrimer vaccines are ongoing. By changing and increasing the density of carbohydrate antigen, we expect to develop a more efficiency carbohydrate-based anti-cancer vaccine in the very near future.
Subjects
Globo H
vaccine
cancer
SDGs
Type
thesis
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