Molecular epidemiology of hepatitis B viral serotypes and genotypes in Taiwan
Journal
Journal of Biomedical Science
Journal Volume
9
Journal Issue
2
Pages
166-170
Date Issued
2002
Author(s)
Abstract
Subtypes of hepatitis B virus (HBV) have specific geographic distributions and can serve as epidemiological markers. The relationship of HBV serotypes and genotypes in Taiwan and their correlation with the domiciles of origin in 122 patients with chronic HBV infection were investigated. The serotype of HBV was determined by comparing the surface gene encoding amino acids 22-148 of the major surface protein with published sequences. Genotyping of HBV was performed by polymerase chain reaction-restriction fragment length polymorphism. Serotype adw accounted for 70% (85/122) of all HBVs, with the remaining belonging to serotype adr. All adr HBVs were genotype C, regardless of the patient's domicile. Of the 85 adw HBVs, 69 (81%) were genotype B, 10 (12%) were genotype C, 5 (6%) were genotype F and only 1 (1%) was genotype A. In the 31 patients originating from mainland China, the prevalence of adr/genotype C was higher than in the 91 Taiwanese patients (15/ 31 vs. 22/91; p< 0.05). The distribution of the HBV serotypes and genotypes was not significantly different between 17 patients born in Taiwan (6 adw/genotype B, 2 adw/genotype C, 1 adw/genotype F and 8 adr/genotype C) and 14 patients born in mainland China (5 adw/genotype B, 2 adw/genotype C and 7 adr/genotype C). Our results indicate that in Taiwan, most HBVs of serotype adware genotype B, and all HBVs of serotype adr are genotype C. Patients with origins in mainland China have a higher proportion of serotype adr/genotype C infection. Copyright ? 2002 National Science Council, ROC and S. Karger AG, Basel.
SDGs
Other Subjects
amino acid; membrane protein; adult; aged; amino acid sequence; article; China; chronic hepatitis; controlled study; correlation analysis; female; genetic code; genotype; geographic distribution; hepatitis B; Hepatitis B virus; human; major clinical study; male; polymerase chain reaction; prevalence; priority journal; restriction fragment length polymorphism; serotype; Taiwan; ethnology; genetics; Hepatitis B virus; immunology; middle aged; molecular evolution; serotyping; statistics; Taiwan; topography; Hepatitis B virus; Adult; Aged; Evolution, Molecular; Female; Genotype; Hepatitis B; Hepatitis B virus; Humans; Male; Middle Aged; Prevalence; Serotyping; Taiwan; Topography, Medical
Type
journal article