APOA1/C3/A5 haplotype and risk of hypertriglyceridemia in Taiwanese
Journal
Clinica Chimica Acta
Journal Volume
390
Journal Issue
1-2
Pages
56-62
Date Issued
2008
Author(s)
Abstract
Background: Apolipoprotein A5 gene (APOA5) has been shown to modulate plasma triglyceride concentrations. We investigated 2 distinct APOA1/C3/A5 haplotypes roles for hypertriglyceridemia. Methods: We recruited 308 cases of hypertriglyceridemia and 281 normal controls from a hospital. Twelve single nucleotide polymorphisms (SNPs) across the APOA1/C3/A5 gene region were genotyped. Results: One haplotype containing the minor alleles of the APOA5 (- 1131T>C, c.553G>T) and APOA1 (- 3013C>T,- 75G>A) was more prevalent in cases than in controls (11.3% vs. 1.1%, respectively) and was statistically significantly associated with high triglycerides (adjusted odds ratio: 12.83, 95% confidence interval [CI]: 5.1-32.4, P < 0.001). Another haplotype that was associated with hypertriglyceridemia (adjusted odds ratio 2.13, 95% CI, 1.37-3.29, P = 0.001). Participants carrying both minor alleles of APOA5-1131CC and c.553TT had a 116% higher triglyceride concentration compared with those carrying common allele. Conclusions: The APOA1/C3/A5 haplotype represents an important locus for predicting risk of hypertriglyceridemia among Taiwanese. ? 2007 Elsevier B.V. All rights reserved.
SDGs
Other Subjects
apolipoprotein A1; apolipoprotein A5; apolipoprotein C3; DNA; allele; APOA1 gene; APOA5 gene; APOC3 gene; article; confidence interval; controlled study; gene; gene locus; haplotype; human; hypertriglyceridemia; major clinical study; prevalence; priority journal; statistical significance; Taiwan; triacylglycerol blood level; Apolipoprotein A-I; Apolipoprotein C-III; Apolipoproteins A; Genetic Predisposition to Disease; Haplotypes; Hypertriglyceridemia; Linkage Disequilibrium; Polymorphism, Single Nucleotide; Risk Factors; Taiwan
Type
journal article