Effects of sex and generation on hepatitis B viral load in families with hepatocellular carcinoma
Journal
World Journal of Gastroenterology
Journal Volume
23
Journal Issue
5
Pages
876-884
Date Issued
2017
Author(s)
Abstract
AIM: To explore factors associated with persistent hepatitis B virus (HBV) infection in a cohort of hepatocellular carcinoma (HCC)-affected families and then investigate factors that correlate with individual viral load among hepatitis B surface antigen (HBsAg)-positive relatives. METHODS: We evaluated non-genetic factors associated with HBV replication in relatives of patients with HCC. Relatives of 355 HCC cases were interviewed using a structured questionnaire. Demographics, relationship to index case, HBsAg status of mothers and index cases were evaluated for association with the HBV persistent infection or viral load by generalized estimating equation analysis. RESULTS: = 0.024) and older siblings were associated with high viral load. CONCLUSION: Sex and generation play important roles on HBV viral load. Maternal birth age and nutritional changes could be the reasons of viral load difference between generations.
Publisher
Baishideng Publishing Group Co., Limited
Type
journal article