Evaluation of the Antimicrobial Activity, Biocompatibility and Microstructure of the Nanocomposites from Silver Nanoparticles Immobilized on Organically Modified Nano Silicate Platelets and Poly(carbonate)urethane
Date Issued
2012
Date
2012
Author(s)
Chi, Ting-Yen
Abstract
Silver nanoparticles (AgNPs) are known for their excellent antimicrobial ability. The antimicrobial ability and the possible induced cytotoxicity of AgNPs depend on particle size and dispersibility. AgNPs are not readily dispersed in most hydrophobic polymers. In this study, an organically modified delaminated clay, in the form of surfactant-capped nanosilicate platelets (“NSQ”), was used to immobilize AgNPs from reduction of silver ion. The nanohybrids of AgNPs and NSQ (“AgNP/NSQ”) provided the possibility of dispersing AgNPs into hydrophobic polymers. AgNP/NSQ in aqueous solution had remarkable bactericidal effect and negligible cytotoxicity and immune response at the overall concentration of 10 ppm. To select model polymers for AgNP/NSQ doping, poly(carbonate)urethane (PCU) with different stoichiometric ratios of hard and soft segments were synthesized. The effect of doing on the physico-chemical properties and microphase separation of the PCU-AgNP/NSQ nanocomposites was determined by the hard/soft segment ratio. The change of microstructure upon doing was confirmed by small-angle X-ray scattering experiments. PCU-AgNP/NSQ nanocomposites containing 75 ppm AgNPs demonstrated superior microbiostatic ability as well as lower immune response and better endothelial cell compatibility and biodurability, compared with the commercial biomedical poly(ether)urethane, Pellethane 2363-80A.
Subjects
Silver nanoparticles
Nanosilicate platelets
Antimicrobial ability
Biocompatibility
Poly(carbonate)urethane
Nanocomposites
Small-angle X-ray scattering
Type
thesis
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