Bioactivities of major constituents isolated from Angelica sinensis (Danggui)
Journal
Chinese Medicine
Journal Volume
6
Date Issued
2011
Author(s)
Chao, Wen-Wan
Abstract
also known as Angelica sinensis (Oliv.) Diels (Apiaceae), has been used in Chinese medicine to treat menstrual disorders. Over 70 compounds have been isolated and identified from Danggui. The main chemical constituents of Angelica roots include ferulic acid, Z-ligustilide, butylidenephthalide and various polysaccharides. Among these compounds, ferulic acid exhibits many bioactivities especially anti-inflammatory and immunostimulatory effects; Z-ligustilide exerts anti-inflammatory, anti-cancer, neuroprotective and anti-hepatotoxic effects; n-butylidenephthalide exerts anti-inflammatory, anti-cancer and anti-cardiovascular effects. ? 2011 Chao and Lin; licensee BioMed Central Ltd.
SDGs
Other Subjects
acetic acid ethyl ester; Angelica sinensis extract; butylidenephthalide; ferulic acid; gamma interferon; glutathione peroxidase; immunoglobulin enhancer binding protein; interleukin 4; isoferulic acid; ligustilide; luciferase; macrophage inflammatory protein 2; malonaldehyde; nitric oxide; prostaglandin; superoxide dismutase; tumor necrosis factor alpha; unclassified drug; Angelica sinensis; antiinflammatory activity; antineoplastic activity; antioxidant activity; apoptosis; brain tumor; cancer inhibition; cell cycle arrest; cell cycle G0 phase; cell cycle G1 phase; danggui; enzyme activation; enzyme inhibition; heart muscle injury; immunomodulation; leukemia; leukocyte count; liver protection; neuroprotection; nonhuman; protein synthesis inhibition; renal protection; review
Type
journal article