MR flow analysis in the measurements of CSF production rate and intracranial pressure
Date Issued
2004-07-31
Date
2004-07-31
Author(s)
DOI
922320B002059
Abstract
The purpose of this study was to
determine the CSF production rate and its
possible circadian variations in healthy young
adults using cine phase-contrast MR imaging
with high temporal and spatial resolutions.
19 healthy adults (15 males, 4 females, 21-39
years of age) were imaged axially
perpendicular to the distal third of the
aqueduct of Sylvius on a 1.5T system, with
30 cardiac phases at 0.39 mm in-plane
resolution. Nine underwent two scans at
1500~1900h and 2100~2400h. Correlation
coefficient maps were generated based on
pixel-by-pixel analysis of temporal flow
patterns, from which the cross-sectional
aqueduct area was defined using a
region-growing algorithm. CSF production
rates were calculated using numerical
integration. The automatic segmentation
approach yielded average CSF production
rate of 332±137 ul/min, which is in good
agreement with literature values obtained
with invasive ventriculolumbar perfusion
measurements. Diurnal change was not
statistically significant (292±79 ul/min at
~1700h and 344±179 ul/min at ~2230h,
respectively, p = 0.16). Based on MR
imaging measurements, a systematic pattern
in circadian variations of CSF production rate
is not evident in humans.
Subjects
CSF production rate
circadian
variation
variation
magnetic resonance imaging
phase contrast
SDGs
Publisher
臺北市：國立臺灣大學電機工程學系暨研究所
Type
report
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