Survival following surgery with or without adjuvant chemotherapy for stage I-IIIA non-small cell lung cancer: An East Asian population-based study
Journal
Oncologist
Journal Volume
17
Journal Issue
10
Pages
1294-1302
Date Issued
2012
Author(s)
Abstract
Background. Asian ethnicity is associated with a distinct molecular etiology, treatment response, and survival outcome among patients with non-small cell lung cancer (NSCLC). This study examines the survival impact of platinum- based adjuvant chemotherapy for Asian patients with stage I-IIIA NSCLC. Methods. This study recruited patients aged ?18 years with histologically proven stage IA-IIIA NSCLC registered in the Taiwan Cancer Registry database in January 2004 to December 2007. Platinum-containing adjuvant chemotherapy had to be started within 90 days of the primary surgery. Kaplan-Meier survival curves, log-rank tests, and the Cox proportional hazards regression model were used to assess the influence of various risk factors on survival time. Results. This study included 2,231 patients with stage IA-IIIA NSCLC who underwent primary surgery with a clear surgical margin. The percentages of all causes of death were significantly lower for the chemotherapy group for both stage II and stage IIIA patients. Multivariate analysis identified platinum-based adjuvant chemotherapy as an independent prognostic factor for the overall survival outcome of stage II (hazard ratio [HR], 0.61; 95% confidence interval [CI], 0.39-0.94; p=.024) and IIIA (HR, 0.71; 95% CI, 0.52- 0.96; p =.029) patients. Among these patients, those who received adjuvant chemotherapy had a superior overall survival outcome for both genders, for the subgroup of patients aged ?70 years, and for those with adenocarcinoma. Conclusion. Platinum-based adjuvant chemotherapy should be considered in the treatment plan for Asian patients with resected stage II and stage IIIA NSCLC. ? AlphaMed Press.
SDGs
Other Subjects
carboplatin; cisplatin; platinum; adjuvant therapy; adult; age; aged; article; Asian; cancer adjuvant therapy; cancer prognosis; cancer surgery; cancer survival; cause of death; controlled study; female; gender; human; lung adenocarcinoma; lung non small cell cancer; major clinical study; male; overall survival; priority journal; retrospective study; risk factor; squamous cell carcinoma; survival time; treatment outcome; Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Chemotherapy, Adjuvant; Cohort Studies; Female; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Survival Rate; Taiwan; Young Adult
Type
journal article