Synthesis of Mesoporous Silica Nanoparticle Encapsulated Alginate Microparticles for Sustained Release and Targeting Chemotherapy
Date Issued
2012
Date
2012
Author(s)
Liao, Yu-Te
Abstract
This study reports the synthesis of mesoporous silica nanoparticles encapsulated alginate microparticles (MSN@Alg) for sustained release and targeting chemotherapy. The MSN@Alg was synthesized by air dynamical atomization, and the effects of several critical factors including concentration of alginate solution, flow rate of alginate solution, flow rate of air, the distance between nozzle and calcium bath, and stirring rate of calcium on the particle size of the synthesized MSN@Alg were investigated. For example, an uniformly distributed, spherical MSN@Alg with 20 um in diameter could be successfully produced when the reaction conditions were chosen as follows: the concentration of alginate solution was 1%, the flow rate of alginate solution was 0.5 mL/min, the flow rate of air was 500 mbar/cm2, the length between nozzle and calcium bath was 6 cm, and the rate of stirring of calcium bath was 300 r.p.m. with 0.3% MSN.
For studying the sustained release properties of the MSN@Alg, rhodamine 6G (R6G) was used as a model drug, and we compared the release properties of R6G/MSN and R6G/MSN@Alg by using different concentrations of alginate, concentrations and volumes of PBS buffer solutions. The sustained release behavior of the R6G/MSN@Alg system can be prolonged to 20 days with an optimal condition of 1 mg R6G/MSN@Alg to 2 mL PBS (10 mM).
For specific targeting chemotherapy, an anti-cancer drug, doxorubicin (Dox), was used to loaded into MSN@Alg, and a RGD-based peptide was functionalized onto the surface of MSN@Alg for the purpose of specific targeting. The results showed that the intracellular drug delivery efficiency was greatly enhanced (i.e, 3.5 folds) for the Dox/MSN@Alg/RGD drug delivery system.
Subjects
alginate
mesoporous silica nanoparticle
sustained release
cell specific targeting
SDGs
Type
thesis
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