行政院國家科學委員會專題研究計畫成果報告:轉綠因子NF-KB與AP-I於神經肌肉疾病中所扮演的角色
Date Issued
1999
Date
1999
Author(s)
楊智超
DOI
882314B002292
Abstract
Immunohistochemical study of subunits of transcription factor NP- i B and AP-l in various neuromuscular disease showed: (1) A majority of necrotic fibers had diffuse immunoactivities(IR) of p50; ER of p65 was only present in a subset. Most of the p50 JR did not co-localize with macrophages; coexistence of p65 and macrophage JR was seen occasionally.(2)In 20-30% of regenerating fibers, there were diffuse p50 and p65 JR. (3) No increase of NP- K B or AP-l JR was observed in neurogenic disorders. (4) For AP-1 IR, c-jun was
increasd in a subset of regenerating fibers but not in necrotic fibers. JR of c-fos was not detected in all biopsies. Our results demonstrate that NF- K B and c-jun can be increascd in human muscle disease. Different distribu ion of NF- K B and AP-1 subunits points to their selective role in muscle patholoy.
Subjects
transcription factor
NF-κB
AP- 1
immunocytochemistry
neuromuscular disease
SDGs
Publisher
臺北市：國立臺灣大學醫學院神經科
Type
journal article
File(s)![Thumbnail Image]()
Loading...
Name
882314B002292.pdf
Size
270.16 KB
Format
Adobe PDF
Checksum
(MD5):a871dce8fbd33b9db861eb6d27653680