The Mechanism Study of Probiotics on Canine Atopic Dermatitis
Date Issued
2012
Date
2012
Author(s)
Chiu, Hsin-Yi
Abstract
Atopic dermatitis (AD) is one of the most common skin diseases that affects children and adults worldwide and its prevalence has been steadily increasing during the past decades. According to the hygiene hypothesis, the decreased exposure of microorganism results in altered T helper cells balance, increasing prevalence and severity of AD. Therefore, probiotics, with their important immune-regulatory potential, has been regarded as a novel strategy for the intervention of atopic disease. In this study, the probiotics, Bacillus subtilis var. natto, has been used for alleviating the symptoms of AD in clinical canine patients. After more than 3 weeks of treatment, the plasma samples were withdrawn from the dogs with significant clinical improvement to execute the proteomics analysis. After the statistical and comparative analysis, we have pinpointed that the down-regulation of apolipoprotein A-I (apoA-I), might get involved in the molecular mechanism mediated by Bacillus subtilis var. natto. Our studies have demonstrated that Bacillus subtilis var. natto could regulate the expression of apoA-I by its immunostimulatory activities and the down-regulation of apoA-I might play roles in the enhancement of its stimulatory effects. Furthermore, we also identified some immunoregulatory proteins, anexin-1, galectin-3 and thromospondin-1 might contribute to anti-AD effects supported by probiotics.
Subjects
atopic dermatitis
Bacillus subtilis var. natto
proteomics
apolipoprotein A-I
immunoregulatory proteins
Type
thesis
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