Applications of co-axial electrospinning fibers in drug delivery
Date Issued
2011
Date
2011
Author(s)
Wu, Yen-Liang
Abstract
The combination of drug delivery and electrospinning received enormous attention, because introducing drugs into electrospun fibers via different ways could enhance the performance of electrospun fibers in different fields. For example, blending growth factors or protein to promote cell adhesion and proliferation or gene phenotype helped the tissue engineering application. In all kinds of drug encapsulation methods, researches in co-axial electrospinning is most popular, due to the versatility of this method on solvent choosing, fine drug distribution through the fibers and sustain release profile and etc.
This research constructed a light induced cross-linked barrier, PAA-Az blend PEG, covered on drug loaded fibers by co-axial electrospinning expect to get more stable release profile. To construct this system, different solvent have been tried. We confirmed the fibrous structure by SEM. Blend FITC into core solution to examined the core-shell structure and FITC distribution by confocal. The anti-inflammatory drug ketoprofen was blended into core electrospinning solution to understand the in vitro release profile. Through the experiment, the core-shell structure electrospun fibers have been produced successfully. But due to high solubility of polymer shell, cause some initial burst release.
Subjects
Electrospinning
co-axial electrospinning
drug delivery
Type
thesis
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