Investigation of the Therapeutic Efficacy of Antitumor Nanodrug Combined with Curcumin Micelles
Date Issued
2014
Date
2014
Author(s)
Yao, Bing-Yu
Abstract
ABSTRACT In this study, we investigated whether liposomal doxorubicin combined with curcumin micelles would have synergistic antitumor effect and decrease the chemotherapy side effect on mice. Male Balb/c mice weighing from 19~22g were used in this study, each mouse received subcutaneous implantation of murine colorectal adenocarcinoma CT-26 cells in both ears. The treatments were initialed on Day 10 when the tumor volumes were about 50mm3. Tumor volumes were measured every three days through Day 28 using digital calipers and the body weights were monitored. Experiments comprised eight groups: Control, Free curcumin(20mg/kg), curcumin micelles low dose(20mg/kg)(CUM20), curcumin micelles high dose(40mg/kg)(CUM40), PLD low dose(4mg/kg)(PLD4), PLD high dose(6mg/kg)(PLD6), PLD6 with CUM20 and PLD4 with CUM40. The results showed that curcumin micelles increased more curcumin accumulation in tumor tissue than free curcumin. Tumor volumes treated with free curcumin, CUM20, and CUM40 were significantly smaller than control after 22 day. The present study showed that PLD6 combined with curcumin micelles was more effective than PLD6 alone. Furthermore, tumor growth in group treated with PLD4 combined with CUM40 was similar to that in group treated with PLD6 alone, but it eased the adverse effect caused by PLD chemotherapy.
Subjects
curcumin
nanodrug
cancer treatment
SDGs
Type
thesis
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