5-Methoxytryptophan attenuates postinfarct cardiac injury by controlling oxidative stress and immune activation
Journal
Journal of Molecular and Cellular Cardiology
Journal Volume
158
Pages
101-114
Date Issued
2021
Author(s)
Abstract
Aims: Myocardial infarction (MI) remains a major cause of heart failure. 5-Methoxytryptophan (5-MTP), a 5-methoxyindole metabolite of L-tryptophan, exerts anti-inflammatory and antifibrotic effects, but MI impairs the biosynthesis of cardiac 5-MTP. Theref
Subjects
5-Methoxytryptophan; Inflammation; Myocardial infarction; NADPH oxidase; Oxidative stress
SDGs
Other Subjects
5 methoxytrptophan; caspase 3; CD11b antigen; interleukin 1; interleukin 18; interleukin 6; monocyte chemotactic protein 1; RANTES; reduced nicotinamide adenine dinucleotide phosphate oxidase; tryptophan derivative; unclassified drug; 5-methoxytryptophan;
Type
journal article