Sample Size Requirements for Pharmacogenetic Studies
Date Issued
2007
Date
2007
Author(s)
Lin, Tzu-Yu
DOI
zh-TW
Abstract
Pharmacogenetic studies investigate the inter-individual variability due to the genetic effect on drug response. Pharmacogenetic studies can be classified to experimental studies and observational studies with or without randomization. In this thesis, we aim to investigate the useful designs, from simple to delicate, in pharmacogenetic studies. In our framework, we use case-control study design to dissect the association between genetic effect and drug response when there is one drug treatment. Furthermore, when there are two or more treatment groups, we detect the effects of treatments, genotypes, and gene-treatment interaction on drug response under trial design. For each design we present the analysis methods for detecting association and the methods for calculation of required sample size. The family-based (sib pairs) design is especially discussed for the intention of setting up a robust design against population stratification.
Subjects
藥理遺傳研究
病體－對照研究
藥理遺傳試驗
同胞對
樣本數
pharmacogenetic study
case-control study
pharmacogenetic trials
sib pairs
sample size
Type
thesis
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