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  4. The Effect of Surgical Weight Reduction on Left Ventricular Structure and Function in Severe Obesity
 
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The Effect of Surgical Weight Reduction on Left Ventricular Structure and Function in Severe Obesity

Journal
Obesity
Journal Volume
18
Journal Issue
6
Pages
1188-1193
Date Issued
2010
Author(s)
Hsuan C.-F.
Huang C.-K.
JOU-WEI LIN  
Lin, Lung-Chun  
Lee T.-L.
Tai C.-M.
Yin W.-H.
Tseng W.-K.
Hsu K.-L.
CHAU-CHUNG WU  
DOI
10.1038/oby.2010.42
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-77952892388&doi=10.1038%2foby.2010.42&partnerID=40&md5=909ba092dadcea0e1f3fb522c4069c8c
https://scholars.lib.ntu.edu.tw/handle/123456789/469798
Abstract
The aim of this study was to examine the effect of surgical weight reduction on cardiac structure and function and to seek the determinants of these changes. Sixty-six severely obese adults (BMI ?35 kg/m2) who received bariatric surgery underwent echocardiographic examination before and 3 months after surgery. At 3 months after surgery, BMI and systolic blood pressure (BP) decreased (43.3 ± 6.3 to 34.1 ± 5.6 kg/m2, P < 0.001, and 146 ± 12 to 130 ± 14 mm Hg, P < 0.001, respectively). In left ventricular (LV) geometry, the relative wall thickness (RWT) and LV mass index decreased significantly (0.43 ± 0.05 to 0.35 ± 0.05, P < 0.001, and 50 ± 11 to 39 ± 11 g/m2.7, P < 0.001, respectively) without changes in chamber size. Multivariate analyses showed change in systolic BP to be an independent predictor for the changes in RWT and LV mass index. In myocardial performance, peak systolic mitral annular velocity and all diastolic indexes showed significant improvements. We concluded that LV hypertrophy and function improved rapidly after bariatric surgery in severely obese adults. BP reduction was the major determinant for the regression of LV hypertrophy in the early stage of surgical weight reduction. ? 2010 North American Association for the Study of Obesity (NAASO).
SDGs

[SDGs]SDG3

Other Subjects
adult; Article; bariatric surgery; body mass; body weight; cardiovascular parameters; clinical trial; diastolic blood pressure; disease severity; early diastolic mitral annular velocity; early to late diastolic mitral inflow velocity ratio; echocardiography; female; heart hemodynamics; heart left ventricle; heart left ventricle function; heart left ventricle hypertrophy; heart left ventricle structure; heart performance; heart rate; human; isovolumetric relaxation time; left ventricular end diastolic dimension; left ventricular geometry; left ventricular mass index; major clinical study; male; obesity; peak systolic mitral annular velocity; prospective study; relative wall thickness; systolic blood pressure; waist circumference; weight reduction; blood pressure; echography; electrocardiography; heart ventricle; middle aged; Obesity, Morbid; pathology; pathophysiology; physiology; weight reduction; young adult; article; bariatric surgery; heart ventricle; morbid obesity; pathology; Adult; Bariatric Surgery; Blood Pressure; Body Weight; Echocardiography; Electrocardiography; Female; Heart Rate; Heart Ventricles; Humans; Male; Middle Aged; Obesity, Morbid; Ventricular Function, Left; Weight Loss; Young Adult; Adult; Bariatric Surgery; Blood Pressure; Body Weight; Echocardiography; Electrocardiography; Female; Heart Rate; Heart Ventricles; Humans; Male; Middle Aged; Obesity, Morbid; Ventricular Function, Left; Weight Loss; Young Adult
Publisher
Blackwell Publishing Inc.
Type
journal article

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