IOP Injection, A Novel Superparamagnetic Iron Oxide Particle MRI Contrast Agent for the Detection of Hepatocellular Carcinoma: A Phase II Clinical Trial
Journal
Journal of magnetic resonance imaging : JMRI
Date Issued
2023-02-11
Author(s)
Chiang, Chi-Feng
Hsu, Yuan-Hung
Hsieh, Wen-Yuan
Liao, Tzu-Hsin
Chen, Chih-Lung
Chen, Yung-Chu
Wang, Shian-Jy
Abstract
MRI is crucial in diagnosing hepatocellular carcinoma (HCC). Superparamagnetic iron oxide particles (SPIO) are liver-specific contrast agents which enhance lesions in T2 -weighted images. Iron oxide nano-particle m-PEG-silane (IOP) Injection, a newly developed SPIO, showed promising imaging effects and good safety profile in preclinical studies and in phase I clinical trial.
Subjects
hepatocellular carcinoma; liver specific contrast agent; magnetic resonance imaging; superparamagnetic iron oxide particles
SDGs
Type
journal article