Drug reaction with eosinophilia and systemic symptoms (DRESS): An interplay among drugs, viruses, and immune system
Journal
International Journal of Molecular Sciences
Journal Volume
18
Journal Issue
6
Date Issued
2017
Author(s)
Abstract
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe multiorgan hypersensitivity reaction mostly caused by a limited number of eliciting drugs in patients with a genetic predisposition. Patients with DRESS syndrome present with characteristic but variable clinical and pathological features. Reactivation of human herpesviruses (HHV), especially HHV-6, is the hallmark of the disease. Anti-viral immune responses intertwined with drug hypersensitivity make the disease more complicated and protracted. In recent years, emerging studies have outlined the disease more clearly, though several important questions remain unresolved. In this review, we provide an overview of DRESS syndrome, including clinical presentations, histopathological features, pathomechanisms, and treatments. ? 2017 by the authors.
Subjects
Drug reaction with eosinophilia and systemic symptoms
Drug-induced hypersensitivity syndrome
Histopathology
Human herpesviruses-6
Pathogenesis
Prognosis
Treatment
SDGs
Other Subjects
abacavir; allopurinol; amoxicillin; ampicillin; azithromycin; boceprevir; carbamazepine; celecoxib; cotrimoxazole; dapsone; diclofenac; ethambutol; gabapentin; ibuprofen; isoniazid; lamotrigine; levofloxacin; minocycline; nevirapine; oxcarbazepine; paracetamol; phenobarbital; phenytoin; piperacillin plus tazobactam; pyrazinamide; rifampicin; salazosulfapyridine; streptomycin; telaprevir; vancomycin; Article; cross reaction; DRESS syndrome; drug sensitization; face edema; fever; gene frequency; Herpes simplex virus; histopathology; HLA system; human; immune system; lymphadenopathy; lymphocytosis; rash; skin biopsy; skin defect; virus reactivation; complication; disease management; disease predisposition; DRESS syndrome; genetic predisposition; host pathogen interaction; immunology; prognosis; symptom assessment; virology; virus activation; virus infection; Disease Management; Disease Susceptibility; Drug Hypersensitivity Syndrome; Genetic Predisposition to Disease; Host-Pathogen Interactions; Humans; Immune System; Prognosis; Symptom Assessment; Virus Activation; Virus Diseases
Publisher
MDPI AG
Type
journal article