Tortuosenes A and B, new diterpenoid metabolites from the formosan soft coral Sarcophyton tortuosum
Journal
Organic Letters
Journal Volume
16
Journal Issue
5
Pages
1314-1317
Date Issued
2014
Author(s)
Abstract
Tortuosenes A and B (1 and 2), possessing new diterpenoid molecular structures, were isolated from the Formosan soft coral Sarcophyton tortuosum along with a known cembrane, emblide (3). The structures of 1 and 2 were established by extensive spectroscopic analysis, and the absolute configuration of 1 was determined by TDDFT ECD calculations. Tortuosene A was found to display significant inhibitory effects on the generation of the superoxide anion in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced neutrophils.
SDGs
Type
journal article