Electrokinetic behavior of a pH-regulated, zwitterionic nanocylinder in a cylindrical nanopore filled with multiple ionic species
Journal
Journal of Colloid and Interface Science
Journal Volume
411
Pages
162-168
Date Issued
2013
Author(s)
Abstract
Recent advances in fabrication techniques make nano-sized pores as promising platforms for both detection and sequencing of individual biopolymers such as DNA. To simulate the electrokinetic behavior of a particle in this case, we consider the electrophoresis of a soft nanocylinder comprising a rigid core and a pH-regulated, zwitterionic polyelectrolyte layer along the axis of a rigid cylindrical nanopore. Extending the conventional electrophoresis analysis, where the liquid phase contains only one kind each of cations and anions, we assume that it contains multiple ionic species, as is usually the case in practice. The key parameters are examined for their influences on the electrokinetic behavior of a particle. These include pH, the thickness of the polyelectrolyte layer and the density of its functional groups, and the pore size. The results gathered provide necessary information for the design of an electrokinetic apparatus. ? 2013 Elsevier Inc.
Subjects
Cylindrical nanopore
Double-layer polarization
Electrophoresis
Multiple ionic species
PH-regulated
Zwitterionic nanocylinder
Type
journal article