Oral post‐radiation malignant fibrous histiocytoma: a clinicopathological study
Journal
Journal of Oral Pathology & Medicine
Journal Volume
23
Journal Issue
7
Pages
324-329
Date Issued
1994
Author(s)
Abstract
Five cases of oral malignant fibrous histiocytoma (MFH) in patients who had previously received radiotherapy in the head or neck region were included in this study. There were 3 men and 2 women. Four patients had been irradiated for nasopharyngeal carcinoma (NPC) and the other for a squamous cell carcinoma (SCC) involving the tongue and mouth floor. The MFH developed 2.5–11 years after the initial radiotherapy. Two cases of MFH occurred in the maxilla, two in the mandible, and the remaining one in the tongue, floor of mouth and mandible. Clinically, the oral post?radiation MFH presented as tender, reddish, elastic, lobulated masses with surface ulceration. Radiographic examination of the involved jaws revealed a poorly defined radiolucent lesion without any periosteal or endosteal reaction. The prognosis of these tumors was very poor. Although aggressive multimodality treatment had been applied, 3 of 5 patients eventually died of the disease, with a mean survival time of 17 months after establishing the diagnosis of MFH. In order to ensure the early diagnosis and treatment of this radiation?induced second malignancy, close oral follow?up is mandatory for patients who have received radiotherapy for head and neck malignancies. Copyright ? 1994, Wiley Blackwell. All rights reserved
Subjects
malignant fibrous histiocytoma; oral cavity; post?radiation sarcoma
SDGs
Other Subjects
adult; article; case report; dermatofibroma; female; head and neck tumor; human; immunohistochemistry; male; mouth tumor; multimodality cancer therapy; pathology; radiation injury; second cancer; skull irradiation; Adult; Case Report; Combined Modality Therapy; Cranial Irradiation; Female; Head and Neck Neoplasms; Histiocytoma, Fibrous; Human; Immunohistochemistry; Male; Middle Age; Mouth Neoplasms; Neoplasms, Radiation-Induced; Neoplasms, Second Primary
Type
journal article