Clinical significance of glutamate metabotropic receptors in renal cell carcinoma risk and survival
Journal
Cancer Medicine
Journal Volume
7
Journal Issue
12
Pages
6104-6111
Date Issued
2018
Author(s)
Hsueh Y.-M.
Chen L.-C.
Cheng W.-C.
Yu C.-C.
Chen W.-J.
Lu T.-L.
Lan K.-J.
Lee C.-H.
Huang S.-P.
Bao B.-Y.
Abstract
Accumulating evidence suggests the roles of glutamate metabotropic receptors (GRMs) in cancer, in addition to synaptic signalling. The present study assessed the associations of genetic variants in eight GRM genes with regard to risk and overall survival (OS) in 780 renal cell carcinoma (RCC) patients and controls. After adjustment for known risk factors, GRM5 rs7102764 T was associated with an increased risk of RCC (P?=?0.006). Additional analysis has provided evidence that rs7102764 T was correlated with a higher expression of GRM5, which is consistently found to be upregulated in tumours, compared to normal tissues. Furthermore, the GRM3 rs701332 C, GRM4 rs2499707 T, and GRM4 rs4713742 T alleles were significantly associated with a poorer OS (P???0.030). The three loci were also observed to have strong cumulative effects on OS. Additional analysis has revealed a significant genotype-expression correlation of rs2499707 T with increased GRM4 expression, which in turn leads to poorer OS in patients with RCC. GRMs might be involved in RCC development and progression, and genetic variants in GRMs might be promising biomarkers. ? 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
Subjects
glutamate metabotropic receptors; prognosis; renal cell carcinoma; single-nucleotide polymorphisms; survival
Other Subjects
metabotropic receptor 3; metabotropic receptor 4; metabotropic receptor 5; metabotropic receptor 7; metabotropic receptor; adult; aged; Article; cancer growth; cancer risk; cancer survival; controlled study; female; gene expression; gene linkage disequilibrium; gene locus; genetic association; genetic variability; genotype; GRM3 gene; GRM4 gene; GRM5 gene; GRM7 gene; human; human tissue; kidney surgery; major clinical study; male; overall survival; priority journal; quantitative trait locus; renal cell carcinoma; risk factor; single nucleotide polymorphism; survival rate; upregulation; genetics; kidney tumor; middle aged; prognosis; renal cell carcinoma; Aged; Carcinoma, Renal Cell; Female; Humans; Kidney Neoplasms; Male; Middle Aged; Polymorphism, Single Nucleotide; Prognosis; Receptors, Metabotropic Glutamate; Risk Factors
Publisher
Blackwell Publishing Ltd
Type
journal article