Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis
Journal
Nature Genetics
Journal Volume
44
Journal Issue
5
Pages
522-525
Date Issued
2012
Author(s)
Lee Y.-C.
Kuo H.-C.
Chang J.-S.
Chen M.-R.
Liang C.-D.
Chi H.
Huang F.-Y.
Lee M.-L.
Huang Y.-C.
Hwang B.
Chiu N.-C.
Hwang K.-P.
Lee P.-C.
Chang L.-C.
Liu Y.-M.
Chen Y.-J.
Chen C.-H.
Chen Y.-T.
Tsai F.-J.
Wu J.-Y.
Abstract
To find new candidate loci predisposing individuals to Kawasaki disease, an acute vasculitis that affects children, we conducted a genome-wide association study in 622 individuals with Kawasaki disease (cases) and 1,107 controls in a Han Chinese population residing in Taiwan, with replication in an independent Han Chinese sample of 261 cases and 550 controls. We report two new loci, one at BLK (encoding B-lymphoid tyrosine kinase) and one at CD40, that are associated with Kawasaki disease at genome-wide significance (P < 5 × 10 -8). Our findings may lead to a better understanding of the role of immune activation and inflammation in Kawasaki disease pathogenesis. ? 2012 Nature America, Inc. All rights reserved.
SDGs
Other Subjects
B lymphoid tyrosine kinase; CD40 antigen; protein tyrosine kinase; unclassified drug; article; controlled study; gene locus; gene replication; genetic association; genetic risk; genetic susceptibility; genotype; human; intron; mucocutaneous lymph node syndrome; priority journal; single nucleotide polymorphism; Case-Control Studies; Genetic Loci; Genetic Markers; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Mucocutaneous Lymph Node Syndrome; Polymorphism, Single Nucleotide; Taiwan
Type
journal article