賀爾蒙、新陳代謝指標與青少年憂鬱：前瞻性雙胞胎家庭追蹤研究(1/2)
Other Title
Hormones and Metabolic Profiles in Relation to Adolescent Depression ：A
Prospective Follow-up study of Twin Families
Prospective Follow-up study of Twin Families
Date Issued
2005-07-31
Date
2005-07-31
Author(s)
陳為堅
DOI
932320B002069
Abstract
Changes in hormones and metabolic profiles during adolescence have been associated with
depression in this developmental period. However, previous studies could not distinguish
between genetic influences and shared environmental influences on these associations. Although
twin studies are an ideal design for this purpose, few had collected blood sample and conducted a
thorough examination on hormones and metabolic indexes. In this study we plan to conduct a
twin-family analysis on 252 twin/sib-pair families that were established for investigating
potential genetic contribution to insulin sensitivity and beta cell function during 2002-2005. The
cohort consisted of 1127 individuals, including 190 twin pairs, 7 triplets (one member of one
triplet wasn’t recruited), 55 sib-pairs, 138 non-proband siblings, and 479 parents
The original proposal was aimed to examine the relationship of hormones and metabolic
profiles with adolescent depression among 180 twin/sib-pair families in a 3-year follow-up
schedule. At the first year, the baseline measurement of hormones and metabolic profiles will be
tested using the stored blood samples. Besides, a total of 45 twin/sib-pair families will be
followed-up for oral glucose tolerance test and psychiatric interview as well as self-report
questionnaires at the same period. We planned to complete the follow-up assessment among
another 90 families at the second-year study period. In the last year we will complete the
follow-up assessment on the remaining 45 twin/sib-pair families. The present study, however,
was approved for 2-year duration. Besides, at the completion of the aforementioned study, i.e.,
insulin sensitivity and beta cell function study, the recruited cohort was expanded to 252
twin/sib-pair families. Because most of the probands can participate in the follow-up examination
only during weekends or summer/winter recess, it is practically not feasible to accomplish the
follow-up of the whole cohort in 2-year period. In the future, we’ll apply for a third year plan to
complete the follow-up of the 252 families.
As of May, 2005, among 252 cohort families, we have contacted 155 (61.5 ％) twin/sib-pair
families and successfully followed and interviewed 45 families. In the first year, we have tested
the stored blood sample of the twin/sib-pair families for the baseline hormones, including cortisol,
dehydroepiandrosterone, leptin, estradiol, and testosterone among 512 twin/sib-pair probands.
The research site was relocated due to the reconstruction of original research building. The
recruitment timeline, however, was in progress as scheduled. Structural equation modeling as
well as correlated frailty models will be used to estimate the contributions of genes, common
environment, and nonshared environment to adolescent depression in these twin-families.
Subjects
Adolescent depression
twin study
hormones
metabolic profiles
Publisher
臺北市：國立臺灣大學公共衛生學院流行病學研究所
Type
report
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